Bioactive Small Molecules
![Medchemexpress LLC 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline | 1206711-16-1 | 99.8% | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230139.png-250.jpg)
Medchemexpress LLC 4-[6-[4-(1-methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline | 1206711-16-1 | 99.8% | 5 MG
DMH-1 (Standard) is an analytical standard of DMH-1, a selective bone morphogenetic protein (BMP) type I receptor inhibitor used as a reference in biochemical and cell-based assays. It exhibits IC50s of 27 nM (ALK1), 107.9 nM (ALK2), <5 nM (ALK3), and 47.6 nM (ALK6).
- Analytical standard for assay calibration and reference.
- Selective BMP type I receptor inhibitor targeting ALK1, ALK2, ALK3, and ALK6.
- Documented IC50s for ALK receptors support target-specific studies.
- High-purity solid suitable for analytical use (99.78% by supplier certificate).
- Available in small milligram quantities for research applications.
Cayman Chemical ANTIBODY GSK5959 10mg
A potent, selective, and cell-permeable inhibitor of the BRPF1 bromodomain (IC50 = 80 nM); disrupts chromatin binding of BRPF1 in a cellular assay by blocking the interaction of BRPF1 with histone H3.3
Cayman Chemical ANTIBODY LOC1886 10mg
A GPX4 inhibitor (Ki = 102 µM); covalently binds to GPX4U46C and inhibits GPX4-mediated reduction of phospholipid hydroperoxides in HT-1080 cell lysates at 100 µM; increases lipid peroxidation in HT-1080 cells at 100 µM
eMolecules 2088410-46-0 | Medchem Express | GSK620 | 5mg | 582658787 | HY-137892 | 325.368 | C18H19N3O3
Ambeed | 2-Bromo-NN-dimethylpyridin-4-amine | 250mg | 525138864 | A228102 | 396092-82-3 | MFCD11036210 | 201.067 | C7H9BrN2
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Medchemexpress LLC GSK2636771 | 1372540-25-4 | C22H22F3N3O3 | 50 MG
GSK2636771 is a potent, selective, and orally bioavailable inhibitor of PI3Kβ with a Ki of 0.89 nM and an IC50 of 5.2 nM. It demonstrates high selectivity, showing 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms. In cellular assays, GSK2636771 treatment significantly decreases cell viability in p110β-reliant PTEN-deficient PC3 prostate and BT549 and HCC70 breast cancer cell lines. Inhibition of p110β leads to a marked decrease of AKT phosphorylation in these cancer cell lines.
- Potent, selective, and orally bioavailable PI3Kβ inhibitor
- High selectivity over p110α, p110γ, and p110δ isoforms
- Decreases cell viability in p110β-reliant cancer cell lines
- Leads to a marked decrease of AKT phosphorylation in cancer cell lines
- Useful for research in cancer and related signaling pathways
Enzo Life Sciences 7-Aminoactinomycin D (1mg). CAS: 7240-37-1
Fluorescent, intercalating DNA-binding agent useful for identifying apoptotic cells by flow cytometry. Capable of identifying populations representing live, apoptotic, and late apoptotic/dead cells in a quick, simple, reproducible, cost-effective fashion. Inhibitor of DNA-primed RNA polymerase and DNA polymerase. Cytochemical probe. Exhibits growth-inhibitory activity against certain leukemias and sarcomas. has antibacterial properties. Alternative name: 7-AAD, 7AAD. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (20mg/ml), methanol or 100% ethanol. Slightly soluble in water. Long Term Storage: -20°C.
Cayman Chemical BAY 85-3934 10mg
A pan-HIF-PH inhibitor (IC50s = 0.48, 0.28, and 0.45 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively); stabilizes HIF-1α and HIF-2α levels in HeLa cells; induces cell-cycle arrest at the G2/S phase in MDA-MB-231 cells at 50 µM; decreases LDH release from PC12 cells in an in vitro model of oxygen-glucose deprivation-induced ischemia at 100 µM; increases plasma erythropoietin and hemoglobin levels, as well as packed cell volume, in a rat model of gentamicin-induced kidney failure at 5 mg/kg
Cayman Chemical cIsFlupenthIxolhydrochLRI 5mg
A typical antipsychotic; dopamine D2 receptor antagonist (Ki = 0.38 nM); 5-HT2A inverse agonist (Ki = 7 nM); reduces cocaine-induced locomotor activity and prevents development of conditioned place preferences for the immediate effects of intravenously administered cocaine in rats at 0.5 mg/kg; inhibits acid sphingomyelinase activity by 81.8% at 10 mM
Cayman Chemical ANTIBODY TFAP 5mg
An inhibitor of COX-1 (IC50 = 0.8 μM); selective for COX-1 over COX-2 (IC50 = 210 μM); reduces acetic acid-induced writhing in mice at 10 and 30 mg/kg; has analgesic activity in the formalin test in rats at 30 mg/kg; does not induce gastric damage in rats at doses up to 300 mg/kg
Medchemexpress LLC PACAP (1-27), human, ovine, rat | 127317-03-7 | 99.3% | 3147.66 | 500 UG
PACAP (1-27), human, ovine, rat (PACAP 1-27) is the N-terminal fragment of PACAP-38. This peptide functions as a potent PACAP receptor agonist, making it suitable for various research applications.
- Functions as a potent PACAP receptor agonist with specific IC50s for rat PAC1 (3 nM), rat VPAC1 (2 nM), and human VPAC2 (5 nM).
- Demonstrated inhibitory effects on increased total pulmonary resistance caused by allergens or histamine in guinea pigs.
- Exhibits high solubility, dissolving at 100 mg/mL in DMSO and ≥ 50 mg/mL in water.
- Stable for 2 years as a powder when stored at -80°C; up to 6 months in solvent at -80°C in sealed storage away from moisture.
TARGETMOL CHEMICALS INC LEM-14-1189 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Lem-14-1189 a LEM-14 derivative is a potent NSD inhibitor of the nuclear receptor binding SET domain and has inhibitory effects on NSD1 NSD2 and NSD3 with IC50 of 418 uM 111 uM and 60 uM respectively. LEM-14-1189 has potential anticancer activity and can be used to study multiple myeloma (MM) and diseases of the blood system. purity: 97%
Cayman Chemical ANTIBODY T-5342126 10mg
A TLR4 antagonist; reduces LPS-induced NO production in RAW 264.7 cells (IC50 = 27.8 µM) and LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 µM, respectively); reduces ethanol intake and the abundance of Iba1 in the central nucleus of the amygdala in ethanol-dependent mice at 82 mg/kg
Medchemexpress LLC Vevorisertib | 1416775-46-6 | 98.0% | C35H38N8O | 10MG
Vevorisertib is an orally active, selective pan-AKT serine/threonine kinase inhibitor provided for research use. It inhibits AKT1, AKT2, and AKT3 with low-nanomolar potency and is intended for in-vitro and preclinical studies; it is not for human use. The compound has formula C35H38N8O, molecular weight 586.73, and a reported purity of about 98%.
- Potent inhibition of AKT isoforms at low nanomolar concentrations.
- Suitable for in-vitro and preclinical cancer research.
- High chemical purity appropriate for biological testing.
- Well-characterized small-molecule with published identifiers and IUPAC name.
- Available in small pack sizes to support laboratory workflows.
Cayman Chemical ANTIBODY p p-DDE 100mg
A metabolite and degradation product of the pesticide DDT; accumulates in various fish and sediment surrounding a DDT manufacturing plant; inhibits estrogen binding to rtERs (IC50 = 8 µM); induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; decreases ATP levels, the proportion of sperm with high mitochondrial membrane potential, and motility of human sperm in vitro from 50-100 µM